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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: Esophageal cancer-related gene-4 ( ) is cloned from the normal epithelium of the esophagus.correlated with the malignant phenotype of tumor cells, validating that is a real tumor suppressor geneEcrg4 is expressed in a wide variety of other cells/tissues, including cardiomyocytes and conductionHere, we briefly review the latest discoveries on Ecrg4 and its underlying molecular mechanisms as atumor suppressor and focus on the emerging roles of Ecrg4 in the CVS.

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer

Jing Liu, Jinbo Yue, Ligang Xing, Jinming Yu

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 172-179 doi: 10.1007/s11684-013-0268-0

Abstract: chemoradiotherapy (nCRT) followed by surgery is gaining popularity as a treatment strategy for locally advanced esophagealcancer.longer than non-responders, indicating that pCR is a significant prognostic factor for patients with esophagealcancer.

Keywords： esophageal cancer     neoadjuvant     chemoradiotherapy    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic andIn esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, butDNA methylation is related to survival time and sensitivity of chemoradiotherapy.This review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract:

Many gene fusions have been recognized as important diagnostic and/or prognostic markers in humanIn recent years, novel gene fusions have been identified in cases without prior knowledge of the geneticThis review focused on advanced genome-wide screening approaches in fusion gene identification, suchas microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression systemThe fundamental rationale and strategy for fusion gene identification using each biotech platform are

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-relatedCytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitorsSome unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: The aim of this article was to investigate the influence and the related mechanism of the gene on glucoseRadioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressioninsulin receptor substrate-1(IRS-1), phosphatidylinositol 3-kinase (PI-3K), AKT-2, glucose transporter-4(GLUT-4), p38 mitogen-activated protein kinase (p38MAPK) and glycogen synthase kinase-3b (GSK-3).Resistin could induce insulin resistance in adipocytes, which might be related to the changes of some

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China.Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine doi: 10.1007/s11684-023-1008-8

Abstract: Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent geneexpression in human cancer.We observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and geneacted as a central element to regulate aberrant gene expression.enhancers in each loop anchor that connects with promoters led to the inhibition of their corresponding gene

Keywords： 3D genome     cancer     TADs     loop     gene regulation    

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Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 131-136 doi: 10.15302/J-FASE-2016096

Abstract: The accumulation of AsA, the expression patterns of the nine genes related to AsA metabolism as well

Keywords： Chinese jujube     ascorbic acid     metabolism     gene     enzyme    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract: Tumor progression is a complex process regulated by a gene network.The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularWe used TCGA data sets and GeneCards database to screen MTA1-related genes.Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, suchthe closest relationship in a coregulation process with the key molecules AKT1, EP300, CREBBP, SMARCA4,

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 1,   Pages 30-38 doi: 10.15302/J-FEM-2016008

Abstract: The authors observed that the gene frequencies of 34 single-nucleotide polymorphisms (SNPs) in threeThe results indicated that SNP rs6069499 within linked CBLN4 gene are strongly associated with accidentAccording to CBLN4 gene mainly involved in adrenal development and the regulation of secretion, the authors

Keywords： accident proneness     genome-wide association study (GWAS)     dopamine (DA)     ACTH     susceptibility gene     traffic    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor geneECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expressionThis review provides an updated summary on the biology of ECRG4, with emphasis on its important rolesin cancer diagnosis and therapy.The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract:

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignantMolecular biology techniques, particularly gene expression microarrays, proteomics, and next-generationThis review focuses on the molecular classification of NSCLC based on gene expression microarray technology

Keywords： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression    

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Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: RNA interference (RNAi) was used to silence the expression of the murine cdk4 gene .The gene silencing efficacy rates of the 3 targets were compared by Western blotting.The cdk4-siRNA2 was the most effective in silencing cdk4.Lentivector-mediated RNAi could efficiently down-regulate the expression of the murine cdk4 gene , whichprovides a potential tool for studying and treating cdk4-related diseases.

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

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Title Author Date Type Operation

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer

Jing Liu, Jinbo Yue, Ligang Xing, Jinming Yu

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Journal Article

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Journal Article

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article